*denotes corresponding authors
1denotes equally contributing first authors


30S. Mayer and K. Lang*,
Tetrazines in Inverse-Electron-Demand Diels–Alder Cycloadditions and Their Use in Biology, Synthesis 2017, 49, 830


29L. Jiao* and K. Lang*, The 6th Sino-German Frontiers of Chemistry Symposium, Chem Asian J. 2016, 11, 3292


28 T. Yu-Hsuan, S. Essig, J. James, K. Lang, and J.W. Chin*
Selective, rapid and optically switchable regulation of protein function in live mammalian cells
Nature Chemistry 2015, 7, 554.
27 T. Machida, K. Lang, L. Xue, J.W. Chin and N. Winssinger*
Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne
Bionconjugate Chemistry 2015, 26, 802.
26 C. Uttamapinant, J.D. Howe, K. Lang, V. Beranek, L. Davis, M. Mahesh, N.P. Barry* and J.W. Chin*
Genetic code expansion enables live-cell and super-resolution of site-specifically labelled cellular proteins
Journal Am. Chem. Soc 2015, 137, 4602.
25 K. Lang*, L. Davis* and J.W. Chin
Genetic Encoding of Unnatural Amino Acids for Labeling Proteins
Methods in Molecular Biology 2015, 1266, 217.


24 K. Wang, A. Sachdeva, D.J. Cox, N.W. Wilf, K. Lang, S. Wallace, R.A. Mehl and J.W. Chin*
Optimized orthogonal translation of unnatural amino acids enables spontaneous protein double labelling and FRET
Nature Chemistry 2014, 6, 393.
23 T.S Elliott, F.M. Townsley, A. Bianco, R.J. Ernst, A. Sachdeva, S.J. Elsässer, L. Davis, K. Lang, R. Pisa, S. Greiss, K.S. Lilley and J.W. Chin*
Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal
Nature Biotechnology 2014, 32, 465.
22 K. Lang*, J.W. Chin*
Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins
Chemical Reviews 2014, 114, 4764.
21 D. Perez-Fernandez, D. Shcherbakov, T. Matt, N.C. Leong, I. Kudyba, S. Duscha, H. Boukari, R. Patak, S.R. Dubbaka, K. Lang, M. Meyer, R. Akbergenov, P. Freihofer, S. Vaddi, P. Thommes, V. Ramakrishnan, A. Vasella, E.C. Böttger
4'-O-substitutions determine selectivity of aminoglycoside antibiotics
Nature Communications 2014, 5:3112, doi: 10.1038/ncomms4112.
20 K. Lang*, J.W. Chin*
Bioorthogonal reactions for labeling proteins
ACS Chemical Biology 2014, 9, 16.


19 K. Lang* and J.W. Chin*
Fluorescence imaging: shining a light into live cells
Nature Chemistry 2013, 5, 81.


18 A. Bianco, F. Townsley, S. Greiss, K. Lang, and J.W. Chin*
Expanding the genetic code of drosophila melanogaster
Nature Chem. Biol. 2012, 8, 748.
17 T. Matt1, C.L. Ng1, K. Lang1, S.H. Sha1, R. Akbergenov1, D. Shcherbakov1, M. Meyer, S. Duscha, J. Xie, S.R. Dubbaka, D. Perez-Fernandez, A. Vasella, V. Ramakrishnan, J. Schacht, E.C. Böttger*
Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin
PNAS 2012, 109, 10984.
16 K. Lang, L. Davis, S. Wallace, M. Mahesh, D.J. Cox, M.L. Blackman, J.M. Fox, J.W. Chin*
Genetic encoding of bicyclononynes and trans-cyclooctenes for site-specific protein labeling in vitro and in live mammalian cells via rapid fluorogenic Diels-Alder reactions
Journal Am. Chem. Soc. 2012, 134, 10317.
15 K. Lang1, L. Davis1, J. Torres-Kolbus, C. Chou, A. Deiters*, J.W. Chin*
Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction
Nature Chemistry 2012, 5, 298.


14 S. Virdee, P.B. Kapadnis, T. Elliott, K. Lang, J. Madrzak, D.P. Nguyen, L. Riechmann, J.W. Chin*
Traceless and site-specific ubiquitination of recombinant proteins
Journal Am. Chem. Soc. 2011, 133, 10708.


13 L. Ng1, K. Lang1, N. Meenan, A. Sharma, A. Kelley, C. Kleanthous*, V. Ramakrishnan*
Structural basis for ribosomal 16S rRNA cleavage by the cytotoxic domain of colicin E3
Nature Struct. and Mol. Biology 2010, 17, 1241.


12 U. Rieder, K. Lang, C. Kreutz, N. Polacek, R. Micura*
Evidence for pseudoknot formation of class I preQ1 riboswitch aptamers
ChembioChem 2009, 10, 1141.
11 V. Olieric, U. Rieder, K. Lang, A. Serganov, C. Schulze-Briese, R. Micura, P. Dumas, E. Ennifar*
A fast selenium derivatization strategy for crystallization and phasing of RNA structures
RNA 2009, 15, 707.


10 K. Lang and R. Micura*
The preparation of site-specifically modified riboswitch domains as an example for enzymatic ligation of chemically synthesized RNA fragments
Nature Protocols 2008, 3, 1457.
9 K. Lang, M.D. Erlacher, D.N. Wilson, R. Micura* and N. Polacek*
The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis
Chemistry & Biology 2008, 15, 485.
8 S. Freisz, K. Lang, R. Micura, P. Dumas and E. Ennifar*
Binding of aminoglycoside antibiotics to the duplex form of the HIV-1 genomic RNA Dimerization Initiation Site
Angew. Chem. Int. Ed. Engl. 2008, 47, 4110.


5 M.D. Erlacher, K. Lang, B. Wotzel, R. Rieder, R. Micura* and N. Polacek*
Efficient ribosomal peptidyl transfer critically relies on the presence of the ribose 2’-OH at A2451 of 23S rRNA
Journal Am. Chem. Soc. 2006, 128, 4453.
4 H. Moroder, C. Kreutz, K. Lang, A. Serganov, and R. Micura*
Synthesis, oxidation behavior, crystallization and structure of 2’-methylseleno guanosine containing RNAs
Journal Am. Chem. Soc. 2006, 128, 9909.
3 R. Micura, C. Höbartner, R. Rieder, C. Kreutz, B. Puffer, K. Lang, H. Moroder
Preparation of 2’-deoxy-2’-methylseleno-modified RNA
Current Protocols in Nucleic Acid Chemistry 2006, Wiley, C1.15.1 – C1.15.34.


2 M.D. Erlacher, K. Lang, N. Shankaran, B. Wotzel, A. Hüttenhofer, R. Micura, A.S. Mankin and N. Polacek*
Chemical engineering of the peptidyl transferase center reveals an important role of the 2’-hydroxyl group of A2451
Nucleic Acids Research 2005, 33, 1618.
1 C. Höbartner, R. Rieder, C. Kreutz, B. Puffer, K. Lang, A. Polonskaia, A. Serganov, and R. Micura*
Syntheses of RNAs with up to 100 nucleotides containing site-specific 2’-Se-methyl labels for use in X-ray crystallography
Journal Am. Chem. Soc. 2005, 127, 12035.